# OpenEndo

> Open data hub for endometriosis research — clinical trials, papers, funding & policy, refreshed weekly from ClinicalTrials.gov and PubMed. Open source, MIT, built for patients, researchers and policymakers.

## Agents: start here
- [CHECKPOINT.md](https://raw.githubusercontent.com/wckdboy/openendo/main/CHECKPOINT.md): living task board — current focus, horizon tasks, blockers, change log (READ FIRST)
- [AGENTS.md](https://raw.githubusercontent.com/wckdboy/openendo/main/AGENTS.md): repo rules for agents

## Site
- [Dashboard](index.html): live analytics — recruiting trials worldwide/by country, Denmark status, PubMed output, funding watch with deadlines
- [Knowledge base (human hub)](wiki.html): rendered wiki index — entities, concepts, comparisons, research program
- [Style guide](styleguide.html): design system, brand, logo, colors, typography, voice & tone
- [How to support](support.html): seven ways to contribute, effort-tagged
- [AI & compute agenda](ai-agenda.html): how AI/agents/compute can move endometriosis research
- [One-pager for decision-makers (EN)](one-pager-en.html): source-backed fact sheet with three asks
- [One-pager for decision-makers (DA)](one-pager-dk.html): dansk fact-side med tre krav

## Machine-readable data (JSON, weekly)
- [Recruiting trials worldwide](data/trials_global_recruiting.json)
- [All registered trials in Denmark](data/trials_denmark.json)
- [New/updated trials, last 7 days](data/trials_recent.json)
- [New papers, last 7 days](data/pubmed_recent.json)
- [Papers per month, 6 months](data/pubmed_monthly.json)
- [Funding opportunities with deadlines](data/funding.json)
- [Editorial content (EN/DA)](data/content.json)
- [Generation metadata](data/meta.json)

## Knowledge base
> Knowledge pages are served as raw markdown from raw.githubusercontent.com (GitHub Pages does not serve .md files). The [human hub](wiki.html) renders the same content with design.
- [SCHEMA](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/knowledge/SCHEMA.md): conventions for creating/editing knowledge pages (agents must read)
- [Index](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/knowledge/index.md): catalog of knowledge pages
- [Entities — ryeqo](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/knowledge/entities/ryeqo.md): relugolix combo, EU-approved, generelt tilskud in DK
- [Entities — yselty](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/knowledge/entities/yselty.md): linzagolix, EU-approved Dec 2024, DK access unverified
- [Entities — hmi-115](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/knowledge/entities/hmi-115.md): first non-hormonal therapy in Phase 3
- [Concepts — gnrh-antagonists](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/knowledge/concepts/gnrh-antagonists.md): the class behind Ryeqo/Yselty
- [Concepts — saliva-diagnostics](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/knowledge/concepts/saliva-diagnostics.md): non-invasive testing vs diagnostic delay
- [Comparisons — ryeqo vs yselty](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/knowledge/comparisons/ryeqo-vs-yselty.md)

## Research (Percival's workstream, merged)
- [M1 fold-input pack](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/research/structures/fold_input/README.md): 35 novel drug targets, AlphaFold-ready
- [Target audit data](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/research/targets/targets.json): 58 targets, ChEMBL-verified, 35 novel
- [T7 lab software modernization track](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/research/lab-software-modernization.md): Danish lab software roadmap
- [M2 living evidence — latest digest](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/research/evidence/digest-2026-09-02.md): weekly evidence synthesis (PubMed + Europe PMC)
- [M2 evidence weekly data](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/research/evidence/weekly/2026-09-02.json): machine-readable evidence snapshot
- [M3 repurposing screen](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/research/evidence/digest-2026-09-02.md): 9 drug-repurposing candidates (see digest)
- [Integration contract — RO-Crate](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/research/tools-and-integration.md): how the hub plugs into ELN/LIMS/repositories
- [RO-Crate manifest (machine-readable)](https://raw.githubusercontent.com/wckdboy/openendo/main/docs/data/ro-crate-metadata.jsonld): FAIR packaging of all datasets
- [Target intelligence (site section 06)](index.html): doughnut + KPIs — 35 novel / 8 approved / 58 audited

## Contributing
- [CONTRIBUTING](https://raw.githubusercontent.com/wckdboy/openendo/main/CONTRIBUTING.md): PR checklist, quality bar, review workflow
- [BRAND](https://raw.githubusercontent.com/wckdboy/openendo/main/BRAND.md): machine-readable brand spec for agents
- [LICENSE](https://raw.githubusercontent.com/wckdboy/openendo/main/LICENSE): MIT — the data is a public good