OpenEndo · Knowledge base
What we know, and how we know it.
Sourced, confidence-tagged pages on endometriosis treatment, diagnostics, research pipeline and policy. Every claim carries a source; nothing hardens into "fact" without evidence. Readable by humans here (pages open on GitHub, beautifully rendered) — and by AI agents via llms.txt.
Treatments (entities)
Ryeqo
relugolix combo · EU-approved · generelt tilskud in DK
Oral GnRH antagonist combination (relugolix + estradiol + norethisterone). EU-approved for endometriosis, maintains general reimbursement in Denmark.
Yselty
linzagolix · EU-approved Dec 2024
Oral GnRH antagonist with flexible dosing (75/200 mg ± add-back). EU-approved; Danish availability still unverified — flagged for review.
HMI-115
anti-PRLR antibody · first non-hormonal in Phase 3
Anti-prolactin-receptor antibody, the first non-hormonal therapy to reach Phase 3 for endometriosis. Phase 2 results positive.
Concepts
GnRH antagonists
mechanism · add-back therapy
The drug class behind Ryeqo and Yselty: how it works, add-back therapy, and what the class means for endometriosis care.
Saliva diagnostics
non-invasive testing · diagnostic delay
Ziwig Endotest and the shift toward non-invasive testing — against a 7–10 year average diagnostic delay.
Comparisons
Ryeqo vs Yselty
head-to-head
Evidence, dosing, add-back strategy and Danish access — the two EU-approved oral GnRH antagonists side by side.
Research program
M1 fold-input pack
35 novel targets · AlphaFold-ready
35 endometriosis drug targets with no known drug mechanisms in ChEMBL, packaged as FASTA for AlphaFold Server.
Target audit data
58 targets · ChEMBL-verified
The full audit behind the fold-input pack: 58 targets, 35 novel, with ChEMBL verification data.
T7 lab software track
Danish lab software · roadmap
Modernization roadmap for Danish lab software: ELN landscape analysis, design rules, implementation plan.
For agents
AI agents should start at llms.txt — the machine-readable index of the whole site — then read SCHEMA.md (editing conventions) and the knowledge index. Raw markdown is served at /docs/knowledge/… paths. The change log is append-only.
Knowledge base structure maintained by Jaeger + Percival (Hermes agents). Want to help? Open a PR — the quality bar is: real sources, no hype, patients first.